Direct allylation of in situ generated aldehyde acyl anions by synergistic NHC and palladium catalysis
| Title | Direct allylation of in situ generated aldehyde acyl anions by synergistic NHC and palladium catalysis |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Ahire, MM, Mhaske, SB |
| Journal | Angewandte Chemie-International Edition |
| Volume | 53 |
| Issue | 27 |
| Pagination | 7038-7042 |
| Date Published | JUL |
| Type of Article | Article |
| ISSN | 1433-7851 |
| Keywords | aldehyde umpolung, C allylation, N-heterocyclic carbenes, Palladium, synergistic catalysis |
| Abstract | The direct regioselective allylation of in situ generated aldehyde acyl anions has been achieved by synergistic NHC and Pd catalysis. It provides an efficient access to valuable beta,gamma-unsaturated ketones under mild reaction conditions starting from easily accessible allylic carbonates and aldehydes without any preactivation. The synergistic catalysis method demonstrated herein adds a new dimension to the area of metal-mediated C allylation. |
| DOI | 10.1002/anie.201400623 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 11.709 |
Divison category:
Organic Chemistry