Reversal of H-bonding direction by N-sulfonation in a synthetic reverse-turn peptide motif
| Title | Reversal of H-bonding direction by N-sulfonation in a synthetic reverse-turn peptide motif |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Vijayadas, KN, Kotmale, AS, Thorat, SH, Gonnade, RG, Nair, RV, Rajamohanan, PR, Sanjayan, GJ |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 13 |
| Issue | 10 |
| Pagination | 3064-3069 |
| Date Published | MAR |
| ISSN | 1477-0520 |
| Abstract | This communication depicts an intriguing example of hydrogen-bonding reversal upon introduction of a sulfonamide linkage at the N-terminus of a synthetic reverse-turn peptide motif. The ready availability of two sulfonyl oxygen atoms, as hydrogen-bonding acceptors, combined with the inherent twisted conformation of sulfonamides are seen to act as switches that engage/disengage the hydrogen-bond at the sticky ends/termini. |
| DOI | 10.1039/c4ob02438a |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.559 |
Divison category:
Center for Material Characterization (CMC)
Central NMR Facility
Organic Chemistry