Total synthesis of (R)-lipoic acid and (S)-lipoic acid via an Mn (III)-salen-catalyzed oxidative kinetic resolution
| Title | Total synthesis of (R)-lipoic acid and (S)-lipoic acid via an Mn (III)-salen-catalyzed oxidative kinetic resolution |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Purude, AN, Pawar, KP, Patil, NB, Kalkote, UR, Chavan, SP |
| Journal | Tetrahedron-Asymmetry |
| Volume | 26 |
| Issue | 5-6 |
| Pagination | 281-287 |
| Date Published | MAR |
| ISSN | 0957-4166 |
| Abstract | The asymmetric synthesis of both the antipodes of alpha-lipoic acid is described. The total synthesis of racemic and asymmetric lipoic acid is achieved from propane 1,3-diol. This work reports the use of Mn (III)-salen-catalyzed oxidative kinetic resolution as the key step to obtain enantiomerically pure (R)- and (S)-lipoic acid. The undesired product formed during the resolution can be recycled to achieve the desired isomer. (C) 2015 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetasy.2015.02.001 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.108 |
Divison category:
Organic Chemistry