Preferential enrichment of DL-leucine using cocrystal formation with oxalic acid under nonequilibrium crystallization conditions
| Title | Preferential enrichment of DL-leucine using cocrystal formation with oxalic acid under nonequilibrium crystallization conditions |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Manoj, K, Takahashi, H, Morita, Y, Gonnade, RG, Iwama, S, Tsue, H, Tamura, R |
| Journal | Chirality |
| Volume | 27 |
| Issue | 7 |
| Pagination | 405-410 |
| Date Published | JUL |
| ISSN | 0899-0042 |
| Keywords | chiral resolution, cocrystal formation, leucine, phase transition, preferential enrichment |
| Abstract | By utilizing the preferential enrichment (PE) technique, we achieved an improved enantiomeric resolution of DL-leucine (Leu) using a 1:1 cocrystal (DL-1) of DL-Leu and oxalic acid. The crystal structure analysis of DL-1 indicated the occurrence of a novel type of phase transition and subsequent preferential redissolution of one enantiomer from the resulting crystals into solution. Chirality 27:405-410 2015. (c) 2015 Wiley Periodicals, Inc. |
| DOI | 10.1002/chir.22431 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.025 |
Divison category:
Center for Material Characterization (CMC)