Chiral aziridine ring opening: facile synthesis of (R)-modletine and (R)-phenoxybenzamine hydrochloride
| Title | Chiral aziridine ring opening: facile synthesis of (R)-modletine and (R)-phenoxybenzamine hydrochloride |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Viswanadh, N, Velayudham, R, Jambu, S, Sasikumar, M, Muthukrishnan, M |
| Journal | Tetrahedron Letters |
| Volume | 56 |
| Issue | 38 |
| Pagination | 5269-5271 |
| Date Published | SEP |
| ISSN | 0040-4039 |
| Keywords | Aziridine, Mexiletine, Phenoxybenzamine |
| Abstract | A simple and efficient synthesis of chiral drugs (R)-mexiletine 1, an anti-arrhythmic drug and (R)-phenoxybenzamine hydrochloride 2, an anti-hypertensive drug has been described via controlled reductive ring opening of chiral aziridine as a key step. The target compounds 1 and 2 were obtained in overall yields of 34% and 10.5%, respectively. (C) 2015 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2015.07.032 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Organic Chemistry