Synthesis of N-aryl beta-amino alcohols by trifluoroacetic acid promoted multicomponent coupling of aziridines, arynes, and water
| Title | Synthesis of N-aryl beta-amino alcohols by trifluoroacetic acid promoted multicomponent coupling of aziridines, arynes, and water |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Roy, T, Baviskar, DR, Biju, AT |
| Journal | Journal of Organic Chemistry |
| Volume | 80 |
| Issue | 21 |
| Pagination | 11131-11137 |
| Date Published | NOV |
| ISSN | 0022-3263 |
| Abstract | A transition-metal-free, three-component coupling involving N-substituted aziridines, arynes, and water promoted by trifluoroacetic acid (TFA) has been reported. The reaction furnished medicinally important N-aryl beta-amino alcohol derivatives in moderate to good yields. In addition, the use of azetidines in this reaction afforded N-aryl gamma-amino alcohol derivatives. |
| DOI | 10.1021/acs.joc.5b01798 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.785 |
Divison category:
Organic Chemistry