Synthesis, biological evaluation and molecular docking studies of N-acylheteroaryl hydrazone derivatives as antioxidant and anti-inflammatory agents
| Title | Synthesis, biological evaluation and molecular docking studies of N-acylheteroaryl hydrazone derivatives as antioxidant and anti-inflammatory agents |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Mahajan, PS, Nikam, MD, Khedkar, VM, Jha, PC, Sarkar, D, Gill, CH |
| Journal | Research on Chemical Intermediates |
| Volume | 42 |
| Issue | 3 |
| Pagination | 2707-2729 |
| Date Published | MAR |
| ISSN | 0922-6168 |
| Keywords | Anti-inflammatory, Antioxidant, Docking study, N-Acylhydrazones, Structure-activity relationship |
| Abstract | In search of new therapeutics with greater potency, three new series of 3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carbohydrazide derivatives have been synthesized and evaluated for their in vitro antioxidant and anti-inflammatory activities. The hydrazones bearing a core pyrazole, chromone and tetrazolo[1,5-a]quinoline scaffold showed promising activities. Interestingly, compounds 3a (EC50 = 06.00 +/- A 2.36) and 5c (EC50 = 07.21 +/- A 0.67) showed the most potent antioxidant activity, while compounds 3a (EC50 = 10.25 +/- A 1.08), 7b (EC50 = 10.50 +/- A 0.99) and 7c (EC50 = 11.18 +/- A 0.15) showed significant anti-inflammatory activity. Furthermore, molecular docking studies also revealed a significant correlation between the binding score and biological activity for these compounds to describe the molecular basis for the structure activity relationship (SAR) results. As these compounds are good cyclooxygenase inhibitors, isoenzyme inhibitory potency studies are warranted. |
| DOI | 10.1007/s11164-015-2176-1 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.833 |