Unusual route to synthesize indolizines through a domino SN2/michael addition reaction between 2‐mercaptopyridine and nitroallylic acetates
| Title | Unusual route to synthesize indolizines through a domino SN2/michael addition reaction between 2‐mercaptopyridine and nitroallylic acetates |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Roy, S |
| Journal | European Journal of Organic Chemistry |
| Issue | 4 |
| Pagination | 765-769 |
| Date Published | JAN |
| Type of Article | Article |
| ISSN | 1434-193X |
| Keywords | domino reactions, Michael addition, nitrogen heterocycles, nucleophilic substitution, synthetic methods |
| Abstract | A straightforward synthesis of indolizines has been demonstrated from the reaction of 2‐mercaptopyridine and nitroallylic acetates in the presence of a base. The products were obtained in good isolated yield under relatively mild reaction conditions. The mechanistic insight of the reaction has been revealed by performing some control experiments demonstrating that the reaction is initiated by a sequential SN2/Michael addition reaction followed by removal of the sulfur moiety. |
| DOI | 10.1002/ejoc.201801426 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.882 |
Divison category:
Organic Chemistry
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