Unlike RNA-TBA (rTBA), iso-rTBA, the 2 `-5 `-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA
| Title | Unlike RNA-TBA (rTBA), iso-rTBA, the 2 `-5 `-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Wagh, AAA, Kumar, VAA, Ravindranathan, S, Fernandes, M |
| Journal | Chemical Communications |
| Volume | 59 |
| Pagination | 1461-1464 |
| Date Published | FEB |
| Type of Article | Article |
| ISSN | 1359-7345 |
| Abstract | An antiparallel, functional RNA G-quadruplex of the 2 `-5 `-linked thrombin-binding aptamer (iso-rTBA) is reported for the first time. It can inhibit clotting and is remarkably stable to nuclease-degradation, besides having high thermal stability. It is thus, a superior candidate to TBA, rTBA or isoTBA, for further development as an anticoagulant. |
| DOI | 10.1039/d2cc05718b |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.065 |
Divison category:
Central NMR Facility
Organic Chemistry
Database:
Web of Science (WoS)