Tubulointerstitial nephritis antigen-like 1 protein is downregulated in the placenta of pre-eclamptic women
| Title | Tubulointerstitial nephritis antigen-like 1 protein is downregulated in the placenta of pre-eclamptic women |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Mary, S, Kulkarni, MJ, Mehendale, SS, Joshi, SR, Giri, AP |
| Journal | Clinical Proteomics |
| Volume | 14 |
| Pagination | Article Number: 8 |
| Date Published | MAR |
| Abstract | Background: Tubulointerstitial nephritis antigen-like 1 protein (TINAGL1), is a matricellular protein, known to play role in cell adhesion and cell receptor interaction. Research related to TINAGL1 is limited to cell culture and animal models. Demonstration of TINAGL1 as a positive regulator of angiogenesis and its expression in the decidua of postimplantation mouse uterus, prompted us to validate its expression in human placenta during impaired angiogenesis in pre-eclamptic condition. Methods: Placental tissue from normotensive (n = 25) and pre-eclamptic (n = 25) pregnancies were used to study the differentially expressed proteins by two-dimensional gel electrophoresis and TINAGL1 protein was validated with Western blotting. Results: A total of 55 protein spots were differentially expressed (fold change > 1.5, p |
| DOI | 10.1186/s12014-017-9144-2 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.476 |
Divison category:
Biochemical Sciences