Triethyl phosphite/benzoyl peroxide mediated reductive dealkylation of O-benzoylhydroxylamines: a cascade synthesis of secondary amides
| Title | Triethyl phosphite/benzoyl peroxide mediated reductive dealkylation of O-benzoylhydroxylamines: a cascade synthesis of secondary amides |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Aegurla, B, Mandle, RD, Shinde, PG, Parit, RS, Kamble, SP, Sudalai, A, Senthilkumar, B |
| Journal | European Journal of Organic Chemistry |
| Volume | 2020 |
| Issue | 27 |
| Pagination | 4235-4238 |
| Date Published | JUL |
| Type of Article | Article |
| ISSN | 1434-193X |
| Keywords | Amides, Cascade reactions, O-Benzoylhydroxylamines, Redox reactions, synthetic methods |
| Abstract | A new triethyl phosphite/benzoyl peroxide (BPO) mediated system has been developed for the synthesis of secondary amides with good to excellent yields in a single step. This unprecedented cascade process involves sequential reduction of N-O bond and benzoylation followed by dealkylation of N-C bond ofO-benzoylhydroxylamines (O-BHA). The methodology is versatile as it tolerates a variety of aromatic and aliphaticO-BHA as substrates to access secondary amides. |
| DOI | 10.1002/ejoc.202000611, Early Access Date = JUN 2020 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.889 |
Divison category:
Chemical Engineering & Process Development
Organic Chemistry