Transition metal free regio-selective C–H hydroxylation of chromanones towards the synthesis of hydroxyl-chromanones using PhI(OAc)2 as the oxidant
| Title | Transition metal free regio-selective C–H hydroxylation of chromanones towards the synthesis of hydroxyl-chromanones using PhI(OAc)2 as the oxidant |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Viswanadh, N |
| Secondary Authors | Ghotekar, GS |
| Tertiary Authors | Thoke, MB |
| Subsidiary Authors | Velayudham, R, Shaikh, AC, Karthikeyan, M, Muthukrishnan, M |
| Journal | Chemical Communications |
| Volume | 54 |
| Issue | 18 |
| Pagination | 2252-2255 |
| Date Published | FEB |
| Type of Article | Journal Article |
| ISSN | 13597345 |
| Abstract | The chromanone scaffold is considered as a privileged structure in drug discovery. Herein, we report a highly efficient PhI(OAc)2 mediated regioselective, direct C–H hydroxylation of chromanones. This method offers easy access to substituted 6-hydroxy chromanones in moderate to good isolated yields, thus paving the way for their pharmaceutical studies. |
| DOI | 10.1039/C7CC08588E |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.319 |
Divison category:
Chemical Engineering & Process Development
Organic Chemistry