Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe

TitleTracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe
Publication TypeJournal Article
Year of Publication2018
AuthorsAli, F, Aute, S, Sreedharan, S, Anila, HA, Saeed, HK, Smythe, CG, Thomas, JA, Das, A
JournalChemical Communications
Volume54
Issue15
Pagination1849-1852
Date PublishedFEB
Type of ArticleArticle
ISSN1359-7345
Abstract

BODIPY derivative, SF-1, exclusively shows a fluorescence ON response to HOCl and images endogenously generated HOCl in RAW 264.7 macrophages. Widefield and super resolution structured illumination microscopy images confirm localization in the Golgi complex and lysosomes, and hence specifically detects HOCl generated in these organelles. SF-1 is compatible with 3D-SIM imaging of individual cells.
DOI10.1039/c7cc09433g
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)6.319
Divison category: 
Organic Chemistry

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