Total synthesis of notoryne
| Title | Total synthesis of notoryne |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Senapati, S, Das, S, Ramana, CV |
| Journal | Journal of Organic Chemistry |
| Volume | 83 |
| Issue | 20 |
| Pagination | 12863-12868 |
| Date Published | OCT |
| Type of Article | Article |
| ISSN | 0022-3263 |
| Abstract | The structure of notoryne comprises a halogenated 2,2'-bifuranyl moiety along with a terminal cis-enyne unit. In this work, we document the first total synthesis of notoryne, confirming its assigned relative and absolute configurations. The devised route comprises a glucose diacetonide-derived chiral pool intermediate as the starting point and 5-endo bromo-etherification for making the key bis-furan unit, anomeric C-allylation, as well as a relay cross-metathesis to install the cis-enyne unit. |
| DOI | 10.1021/acs.joc.8b01757 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.805 |
Divison category:
Organic Chemistry
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