Total synthesis of natural fregenedadiol and its diacetate, rearranged labdanes with aromatized B ring
| Title | Total synthesis of natural fregenedadiol and its diacetate, rearranged labdanes with aromatized B ring |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Philkhana, SChandra, D. Reddy, S |
| Journal | Tetrahedron Letters |
| Volume | 58 |
| Issue | 13 |
| Pagination | 1262-1264 |
| Date Published | MAR |
| Abstract | Labdane based natural products are most abundant and widely distributed in nature with many compounds exhibiting exceptional biological properties. Fregenedadiol is a bicyclic diterpene isolated from Halimium viscosum and represents a new carbon skeleton fregenedane with its B ring aromatized. Here, we report a total synthesis of this interesting natural product using one-pot Diels-Alder/aromatization sequence and selective hydrogenolysis as key steps. (C) 2017 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2017.02.010 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Organic Chemistry