Total synthesis of isocladosporin and 3-epi-isocladosporin
| Title | Total synthesis of isocladosporin and 3-epi-isocladosporin |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Mohapatra, DK, Maity, S, Banoth, S, Gonnade, RG, Yadav, JS |
| Journal | Tetrahedron Letters |
| Volume | 57 |
| Issue | 1 |
| Pagination | 53-55 |
| Date Published | JAN |
| ISSN | 0040-4039 |
| Keywords | Acylation reaction, Cross-metathesis, Iodocyclization, Isocladosporin 3-epi-Isodadosporin, Luche reduction |
| Abstract | A convergent total synthesis of isocladosporin and 3-epi-isocladosporin is reported starting from commercially available homoallyl alcohol in 10 longest linear steps with 28% overall yield. The key steps involved in the synthesis are cross-metathesis, tandem isomerization followed by C-O and C-C bond formation reactions for the synthesis of trans-2,6-disubstituted dihydropyrans developed by us, acylation reaction and Luche reaction. (C) 2015 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2015.11.060 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Physical and Materials Chemistry