Total synthesis of integrastatin B enabled by a benzofuran oxidative dearomatization cascade
| Title | Total synthesis of integrastatin B enabled by a benzofuran oxidative dearomatization cascade |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | More, AA, Ramana, CV |
| Journal | Organic Letters |
| Volume | 18 |
| Issue | 6 |
| Pagination | 1458-1461 |
| Date Published | MAR |
| ISSN | 1523-7060 |
| Abstract | The first total synthesis of integrastatin B, a potent HIV-1 integrase inhibitor, has been accomplished in seven steps with a 17.9% overall yield employing easily accessible starting compounds. The Oxone-mediated oxidative benzofuran dearomatization cascade has been employed as the key skeletal construct to forge the central tetracyclic nucleus. |
| DOI | 10.1021/acs.orglett.6b00404 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.732 |
Divison category:
Organic Chemistry