Total synthesis of an anticancer natural product (+/-)-peharmaline A and its analogues
| Title | Total synthesis of an anticancer natural product (+/-)-peharmaline A and its analogues |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Kulkarni, AS, Shingare, RD, Dandela, R, D. Reddy, S |
| Journal | European Journal of Organic Chemistry |
| Issue | 46 |
| Pagination | 6453-6456 |
| Date Published | DEC |
| Type of Article | Article |
| ISSN | 1434-193X |
| Abstract | First total synthesis of a rare beta-carboline-vasicinone hybrid alkaloid (+/-)-peharmaline A has been accomplished in just 3 steps starting from known compounds. Stereoselective Pictet-Spengler reaction to nitrogenated tertiary carbon center and one-pot construction of the tricyclic skeleton of vasicinone are the highlights of present synthesis. We have also synthesized structurally close analogues of the natural product by following the developed route. |
| DOI | 10.1002/ejoc.201800949 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.882 |
Divison category:
Organic Chemistry