Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials
| Title | Total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate and its antimicrobial potentials |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Said, MS, Udavant, R, Sahu, AKumar, Khan, A, Nayak, R, Dastager, SG, Kumar, P, Gajbhiye, J |
| Journal | Natural Product Research |
| Date Published | JUL |
| Type of Article | Article; Early Access 2020 |
| ISSN | 1478-6419 |
| Keywords | antibacterial activity, butenolide cinnamate, Total synthesis |
| Abstract | The first total synthesis of (-)-2-methoxy-2-butenolide-3-cinnamate (butenolide cinnamate) was achieved using commercially available starting material. The synthesized compound was found to have promising antibacterial activity against Gram-negative strainsEscherichia coli(ATCC 8739),Salmonella typhimurium(ATCC 23564) andPseudomonas aeruginosa(ATCC 19154) with a minimum inhibitory concentration of 2.0 mu g/mL, 1.0 mu g/mL and 2.0 mu g/mL, respectively. Notably, the compound was more potent against Gram-negative test strains than the Gram-positive test strains. |
| DOI | 10.1080/14786419.2020.1789979, Early Access Date = JUL 2020 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.158 |
Divison category:
National Collection of Industrial Micr-organisms (NCIM)
Organic Chemistry