TDR Targets: a chemogenomics resource for neglected diseases

TitleTDR Targets: a chemogenomics resource for neglected diseases
Publication TypeJournal Article
Year of Publication2012
AuthorsMagarinos, MP, Carmona, SJ, Crowther, GJ, Ralph, SA, Roos, DS, Shanmugam, D, Van Voorhis, WC
JournalNucleic Acids Research
Volume40
IssueD1
PaginationD1118-D1127
Date PublishedJAN
AbstractThe TDR Targets Database (http://tdrtargets.org) has been designed and developed as an online resource to facilitate the rapid identification and prioritization of molecular targets for drug development, focusing on pathogens responsible for neglected human diseases. The database integrates pathogen specific genomic information with functional data (e.g. expression, phylogeny, essentiality) for genes collected from various sources, including literature curation. This information can be browsed and queried using an extensive web interface with functionalities for combining, saving, exporting and sharing the query results. Target genes can be ranked and prioritized using numerical weights assigned to the criteria used for querying. In this report we describe recent updates to the TDR Targets database, including the addition of new genomes (specifically helminths), and integration of chemical structure, property and bioactivity information for biological ligands, drugs and inhibitors and cheminformatic tools for querying and visualizing these chemical data. These changes greatly facilitate exploration of linkages (both known and predicted) between genes and small molecules, yielding insight into whether particular proteins may be druggable, effectively allowing the navigation of chemical space in a genomics context.
DOI10.1093/nar/gkr1053
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)9.202
Divison category: 
Biochemical Sciences