Systematic search for a predictor for the clinical observables of alzheimer's disease
| Title | Systematic search for a predictor for the clinical observables of alzheimer's disease |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Das, A |
| Journal | Journal of Physical Chemistry B |
| Volume | 125 |
| Issue | 44 |
| Pagination | 12177-12186 |
| Date Published | NOV |
| Type of Article | Article |
| ISSN | 1520-6106 |
| Abstract | One of the prevailing life-threatening incurable neurodegenerative diseases that are presently endangering human society as a whole, and hence, baffling the entire spectrum of the scientific and pharmaceutical world, is Alzheimer's disease (AD). AD is a manifestation of self-assembly of both wild-type (sporadic) and mutated (familial) forms of the amyloid-beta peptide, a proteolytic product of the amyloid precursor protein, where the self-assembly results in the genesis of pathogenic fibrillar aggregates. Currently prevailing diagnostic and hence therapeutic challenges originate from the unavailability of a specific predictor for clinical observables. The continuous emergence of novel pathogenic mutants with unpredictable phenotypes adds immensely to the nonspecific nature of the problem. The current research reports a simple physical parameter, the binding affinity of a protofilament to its protofibril, which predicts the clinical observables of familial AD with astounding accuracy and more importantly, without any adjustable parameters. |
| DOI | 10.1021/acs.jpcb.1c06725 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.991 |
Divison category:
Physical and Materials Chemistry
Add new comment