Synthetic studies towards Pseudoxylallemycin B, an antibiotic active against gram-negative bacteria: total synthesis of 3-epi-Pseudoxylallemycin B
| Title | Synthetic studies towards Pseudoxylallemycin B, an antibiotic active against gram-negative bacteria: total synthesis of 3-epi-Pseudoxylallemycin B |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Gunjal, VB |
| Secondary Authors | Reddy, SD |
| Journal | Tetrahedron Letters |
| Type of Article | Journal Article |
| Keywords | Cyclic tetrapeptides, Epimerization, Gram-negative bacteria, Macrolactamization, Propyl phosphonic anhydride (T3P) |
| Abstract | In an attempt towards the total synthesis of Pseudoxylallemycin B, a homo dimeric, N-methylated macrocyclic tetrapeptidic natural product, synthesis of its epimer at position 3 (d-Tyr instead of l-Tyr) is described here. During the course of synthesis we came across a striking yet unusual observation of complete epimerization which led to the formation of 3-epi-Pseudoxylallemycin B. |
| DOI | 10.1016/j.tetlet.2018.06.028 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.193 |
Divison category:
Organic Chemistry