Synthesis of methyl-protected (+/-)-chlorizidine A
| Title | Synthesis of methyl-protected (+/-)-chlorizidine A |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Mahajan, JP, Mhaske, SB |
| Journal | Organic Letters |
| Volume | 19 |
| Start Page | 10 |
| Pagination | 2774-2776 |
| Date Published | MAY |
| Type of Article | Article |
| Abstract | The first total synthesis of the methyl-protected (+/-)-chlorizidine A has been achieved in 10 steps. Pd-catalyzed decarboxylative coupling and late-stage oxidation were utilized to, construct the 5H-pyrrolo[2,1-a]isoindol-5-one scaffold. Samarium(II) iodide mediated Reformatsky reaction and intramolecular Mitsunobu reactions were efficiently applied for the synthesis of the 2,3-dihydropyrrolizine ring system. Chlorizidine A is highly prone to degradation; hence, methyl-protected (+/-)-chlorizidine A was prepared. |
| DOI | 10.1021/acs.orglett.7b01090 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.492 |
Divison category:
Organic Chemistry