Synthesis of key intermediate for (+)-tofacitinib through CoIII(salen)-catalyzed two stereocentered hydrolytic kinetic resolution of (±)-methyl-3-(oxiran-2-yl)butanoate
| Title | Synthesis of key intermediate for (+)-tofacitinib through CoIII(salen)-catalyzed two stereocentered hydrolytic kinetic resolution of (±)-methyl-3-(oxiran-2-yl)butanoate |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Kamble, RB |
| Secondary Authors | Suryavanshi, G |
| Journal | Synthetic Communications |
| Volume | 48 |
| Issue | 9 |
| Pagination | 1045-1051 |
| Date Published | MAR |
| Type of Article | Journal Article |
| ISSN | 397911 |
| Keywords | enantioselective, Hydrolytic kinetic resolution, iodolactonization, γ-Butyralactone |
| Abstract | An enantiopure piperidine, a key intermediate for the synthesis of (+)-tofacitinib, has been achieved in high optical purity (98% ee) from readily available crotyl alcohol. The key steps involved is a CoIII(salen)-OAc-catalyzed two stereocentered hydrolytic kinetic resolution of (±)-methyl-3-(oxiran-2-yl)butanoate. |
| DOI | 10.1080/00397911.2018.1434204 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.134 |
Divison category:
Chemical Engineering & Process Development