Synthesis of an indole containing KDR kinase inhibitor by tandem Sonogashira coupling-5-endo-dig-cyclization as a key step
| Title | Synthesis of an indole containing KDR kinase inhibitor by tandem Sonogashira coupling-5-endo-dig-cyclization as a key step |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Palimkar, SS, More, VS, P. Kumar, H, Srinivasan, KV |
| Journal | Tetrahedron |
| Volume | 63 |
| Issue | 51 |
| Pagination | 12786-12790 |
| Date Published | DEC |
| Type of Article | Article |
| ISSN | 0040-4020 |
| Abstract | An efficient synthesis of the potent KDR kinase inhibitor 3-[5-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-1H-indol-2-yl]quin oline-2-(1H)-one using a Sonogashira coupling-5-eiido-dig-cyclization strategy is described. (c) 2007 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tet.2007.09.075 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.645 |
Divison category:
Organic Chemistry