Synthesis of gymnoascolide A
| Title | Synthesis of gymnoascolide A |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Baag, MMerajuddin, Argade, NP |
| Journal | Synthesis-Stuttgart |
| Issue | 1 |
| Pagination | 26-28 |
| Date Published | JAN |
| Type of Article | Article |
| ISSN | 0039-7881 |
| Keywords | dimethyl (bromomethyl)fumarate, functionalized maleic anhydrides, gymnoascolide A, regioselective reduction, S(N)2 ` Grignard coupling reaction |
| Abstract | Recently isolated 4-benzyl-3-phenylfuran-2,5-dione and antifungal gymnoascolide A have been synthesized using the chemoselective S(N)2' coupling of phenylmagnesium bromide with dimethyl 2-(bromomethyl)fumarate, chemoselective allylic substitution of bromide in 3-(bromomethyl)-4-phenylfuran-2,5-dione with phenylmagnesium bromide and regioselective N-Selectride-induced reduction of 3-benzyl-4-phenylfuran-2,5-dione as the key reactions. |
| DOI | 10.1055/s-2007-990901 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.652 |
Divison category:
Organic Chemistry