Synthesis of functionalized 6-hydroxy-2-oxindole derivatives by phenoxide cyclization
| Title | Synthesis of functionalized 6-hydroxy-2-oxindole derivatives by phenoxide cyclization |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | B. Reddy, N, Ramana, CV |
| Journal | Organic Letters |
| Volume | 18 |
| Issue | 24 |
| Pagination | 6264-6267 |
| Date Published | DEC |
| Abstract | An apparent intramolecular cross-dehydrogenative coupling of N-(3-hydrox)monoanilide of maleic esters comprising base promoted phenoxide cyclization and subsequent base-mediated aerobic oxidation was developed to synthesize a variety of 2-(6-hydroxy-2-oxoindolin-3-ylidene)-acetate derivatives. The isolation of intermediate cyclized products during the large scale reactions and their ready dehydrogenation with 1 equiv of base support this proposed two-step path. |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 5.23 |
Divison category:
Organic Chemistry