Synthesis of chiral tetrahydrofuran building blocks from pantolactones: application in the synthesis of empagliflozin and amprenavir analogs
| Title | Synthesis of chiral tetrahydrofuran building blocks from pantolactones: application in the synthesis of empagliflozin and amprenavir analogs |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Athawale, PR, Kumari, N, Kashinath, K, D. Reddy, S |
| Journal | Europen Journal of Organic Chemistry |
| Date Published | JUL |
| Type of Article | Article |
| Abstract | Chiral 4,4-dimethyl tetrahydrofuran (THF) derivatives were synthesized from commercially available D-(-)/ l-(+) pantolactones, which can serve as chiral building blocks in medicinal chemistry. In addition, two of the synthesized building blocks were utilized for the synthesis of new amprenavir (HIV protease inhibitor) and empagliflozin (anti-diabetic) analogs. The synthesized analogs may have beneficial effects in terms of pharmacokinetics and modulation of bioactivity. |
| DOI | 10.1002/ejoc.201900718 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.029 |
Divison category:
Organic Chemistry
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