Synthesis, antioxidant, anti-inflammatory, and antimicrobial screening of newer thiophene-fused arylpyrazolyl 1,3,4-oxadiazoles
| Title | Synthesis, antioxidant, anti-inflammatory, and antimicrobial screening of newer thiophene-fused arylpyrazolyl 1,3,4-oxadiazoles |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Mahajan, PS, Nikam, M, Chate, A, Nimbalkar, U, Patil, V, Bobade, A, Chaudhari, A, Deolankar, D, Javale, B, Gill, CH |
| Journal | Phosphorus Sulfur and Silicon and the Related Elements |
| Volume | 190 |
| Issue | 11 |
| Pagination | 1803-1813 |
| Date Published | NOV |
| ISSN | 1042-6507 |
| Keywords | 1, 3, 4-Oxadiazole, Anti-inflammatory, Antimicrobial, Antioxidant, EC50, Thiophene-fused pyrazole |
| Abstract | A series of newer 1,3,4-oxadiazole derivatives 3a-h, 5a-h containing a thiophene fused with pyrazole moiety of pharmacological significance have been synthesized. The compounds were characterized by H-1 NMR, IR, and mass spectral techniques. The compounds were screened for their in vitro antioxidant, anti-inflammatory and antimicrobial activities. Among them, Compounds 3b (EC50-14.98) and 3f (EC50-12.21) showed significant antioxidant activity. Compound 3a (EC50-15.23) showed good anti-inflammatory activity. Compound 3d was found as the most active derivative against bacterial and fungal strains. |
| DOI | 10.1080/10426507.2015.1024784 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 0.723 |
Divison category:
Chemical Engineering & Process Development