Synthesis and characterization of biocompatible poly (L-lactide) using zinc (II) salen complex
| Title | Synthesis and characterization of biocompatible poly (L-lactide) using zinc (II) salen complex |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Rade, PP, Garnaik, B |
| Journal | International Journal of Polymer Analysis and Characterization |
| Volume | 25 |
| Issue | 5 |
| Pagination | 283-299 |
| Date Published | JUL |
| Type of Article | Article |
| ISSN | 1023-666X |
| Keywords | Biocompatible, Biomedical Applications, in vitro, PLLA, zinc (II) salen complex |
| Abstract | A biocompatible zinc (II) complex based on a tetradentate N,N,O,O-type salen ligand was synthesized, characterized and used for the solvent-free ring-opening polymerization (ROP) of L-lactide in bulk at 180 degrees C to prepare high molecular weight poly(L-lactide) (M-n: 82,600 Da;M-w: 140,000 Da; PDI: 1.70). Poly(L-lactide) (PLLA) was characterized using FTIR,H-1 NMR,C-13 NMR, GPC, TGA, DSC, WAXD, and MALDI-ToF. Kinetic measurement was carried out and first-order behavior to monomer was observed. Thek(app)was found as 6 +/- 0.001 x 10(-4 )s(-1). The biocompatibility of the PLLA was confirmed byin vitrocytotoxicity against NIH/3T3 fibroblast cell line and can be used in biomedical applications. |
| DOI | 10.1080/1023666X.2020.1783496, Early Access Date = JUN 2020 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.716 |
Divison category:
Polymer Science & Engineering