Synthesis and biological evaluation of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives via click chemistry approach
| Title | Synthesis and biological evaluation of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives via click chemistry approach |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Kategaonkar, AH, Shinde, PV, Kategaonkar, AH, Pasale, SK, Shingate, BB, Shingare, MS |
| Journal | European Journal of Medicinal Chemistry |
| Volume | 45 |
| Issue | 7 |
| Pagination | 3142-3146 |
| Date Published | JUL |
| ISSN | 0223-5234 |
| Keywords | 1, 2, 2-Chloro3-formyl quinoline, 3-Triazole, Antibacterial, antifungal, Click chemistry |
| Abstract | Synthesis of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives (4a-h) using 1,3-dipolar cycloaddition (click chemistry) reaction of 3-(azidomethyl)-2-chloro-quinoline derivatives (3a-h) with phenyl acetylene in the presence of Cu(I) catalyst has been achieved in very high yield. These molecules were evaluated in vitro for their antifungal and antibacterial activity. Most of the compounds exhibited significant antifungal and antibacterial activity against all the tested strains. (C) 2010 Elsevier Masson SAS. All rights reserved. |
| DOI | 10.1016/j.ejmech.2010.04.002 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.193 |
Divison category:
Polymer Science & Engineering