Synthesis and antitubercular activity of amino alcohol fused spirochromone conjugates
| Title | Synthesis and antitubercular activity of amino alcohol fused spirochromone conjugates |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Mujahid, M, Gonnade, RG, Yogeeswari, P, Sriram, D, Muthukrishnan, M |
| Journal | Bioorganic & Medicinal Chemistry Letters |
| Volume | 23 |
| Issue | 5 |
| Pagination | 1416-1419 |
| Date Published | MAR |
| ISSN | 0960-894X |
| Keywords | Amino alcohol, Antitubercular activity, Mycobacterium tuberculosis, Spirochromones |
| Abstract | A series of 21 new amino alcohol fused spirochromone conjugates have been synthesized, characterized with analytical data and evaluated their antimycobacterial activity against Mycobacterium tuberculosis (virulent strain H37Rv) in vitro. Some of the compounds exerted significant inhibition, in particular, compound 4f found to be the most potent derivative exhibiting MIC = 3.13 mu g/mL. (C) 2013 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.bmcl.2012.12.073 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.331 |
Divison category:
Center for Material Characterization (CMC)
Organic Chemistry