Synthesis of all four nucleoside-based beta-amino acids as protected precursors for the synthesis of polyamide-DNA with alternating alpha-amino acid and nucleoside-beta-amino acids
| Title | Synthesis of all four nucleoside-based beta-amino acids as protected precursors for the synthesis of polyamide-DNA with alternating alpha-amino acid and nucleoside-beta-amino acids |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Bagmare, S, Varada, M, Banerjee, A, Kumar, VA |
| Journal | Tetrahedron |
| Volume | 69 |
| Issue | 3 |
| Pagination | 1210-1216 |
| Date Published | JAN |
| ISSN | 0040-4020 |
| Keywords | Antisense therapeutics, Neutral DNA analogues, Nucleoside-beta amino acids |
| Abstract | A simple approach is described for the synthesis of all four orthogonally protected nucleoside-beta-amino acids from commercially available starting materials. Synthesis of a model tetrameric DNA sequence in 5'-3'direction employing trityl strategy and glycine as alpha-amino acid alternating with nucleoside-beta amino acids is described. (C) 2012 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tet.2012.11.028 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.817 |
Divison category:
Organic Chemistry