Synthesis of aculeatins A and B via iterative hydrolytic kinetic resolution

TitleSynthesis of aculeatins A and B via iterative hydrolytic kinetic resolution
Publication TypeJournal Article
Year of Publication2010
AuthorsHarbindu, A, Kumar, P
JournalSynthesis-Stuttgart
Issue9
Pagination1479-1484
Date PublishedMAY
ISSN0039-7881
Keywordsaculeatins, Epoxide, Hydrolytic kinetic resolution, Linchpin coupling, spirocyclization
Abstract

A simple and concise approach for the synthesis of aculeatins A and B starting from (+/-)-epichlorohydrin is described. The synthetic strategy features Jacobsen's hydrolytic kinetic resolution and a Linchpin coupling as key steps.

DOI10.1055/s-0029-1218687
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)2.260
Divison category: 
Organic Chemistry