Synthesis of (3S,4R)-4-benzylamino-3-methoxypiperidine, an important intermediate for (3S,4R)-Cisapride
| Title | Synthesis of (3S,4R)-4-benzylamino-3-methoxypiperidine, an important intermediate for (3S,4R)-Cisapride |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Shirode, NM, Likhite, AP, Gumaste, VK, Deshmukh, ARakeeb A |
| Journal | Tetrahedron |
| Volume | 64 |
| Issue | 30-31 |
| Pagination | 7191-7198 |
| Date Published | JUL |
| Type of Article | Article |
| ISSN | 0040-4020 |
| Keywords | 4-aminopiperidine, azetidin-2-ones, Cisapride, Staudinger reaction, stereoselective synthesis |
| Abstract | An efficient synthesis of (3S,4R)-4-benzylamino-3-methoxypiperidine, an useful intermediate for the chiral synthesis of important drug molecule Cisapride and its analogs, from enantiopure 4-formylazetidin-2-one is described. Synthesis of trans as well as cis isomers of 4-amino-3-methoxypiperidine from 4-formylazetidin-2-one is also achieved in good yield. (c) 2008 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tet.2008.05.090 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.645 |
Divison category:
Organic Chemistry