Distillation is one of the most widely used separation unit operations in process industries, although it is quite energy intensive. In many cases, the enormous energy requirements for distillation make it economically infeasible to carry out the separation. Thermally coupled distillation system (TCDS) is an advanced distillation method that provides significant energy savings of about 30% as compared with conventional distillation column sequences. The most well-known TCDS sequence, the Petlyuk configuration, has some operational challenges due to bidirectional vapour flow, which makes its implementation difficult in two-column mode. To overcome these limitations, a number of unidirectional vapour flow configurations have been proposed in the literature. The work on simulation analysis for such configurations is limited. In this paper, simulation models for two such configurations are developed, analyzed and compared with the Petlyuk and conventional distillation column sequences for separation of equimolar mixture of benzene-toluene-ethylbenzene.