Stereoselective synthesis of (-)-microcarpalide
| Title | Stereoselective synthesis of (-)-microcarpalide |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Chavan, SP, Praveen, C |
| Journal | Tetrahedron Letters |
| Volume | 46 |
| Issue | 11 |
| Pagination | 1939-1941 |
| Date Published | MAR |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Keywords | 4-diol, cis-2-butene-1, Claisen ortho ester rearrangement, microcarpalide, Ring-closing metathesis, sharpless asymmetric dihydroxylation |
| Abstract | A highly convergent and efficient synthesis of (-)-microcarpalide, a 10-membered lactone displaying remarkable microfilament disrupting activity is described. Ring-closing metathesis and Sharpless asymmetric dihydroxylations are the key steps. Our strategy highlights the application of novel hydroxy lactone precursors for the stereoselective synthesis of (-)-microcarpalide. (C) 2005 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2005.01.052 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Organic Chemistry