Stereoselective synthesis of the densely functionalized C1-C9 fragment of amphidinolides C and F

TitleStereoselective synthesis of the densely functionalized C1-C9 fragment of amphidinolides C and F
Publication TypeJournal Article
Year of Publication2009
AuthorsMohapatra, DK, Dasari, P, Rahaman, H, Pal, R
JournalTetrahedron Letters
Volume50
Issue46
Pagination6276-6279
Date PublishedNOV
ISSN0040-4039
KeywordsAmphidinolide C and F, Cytotoxic, Tandem dihydroxylation-S(N)2, Wacker oxidation, Wittig reaction
Abstract

The synthesis of the C1-C9 subunit of amphidinolides C and F is described. Key steps include tandem Sharpless asymmetric dihydroxylation-S(N)2 cyclization reaction, Lewis acid-mediated epoxide opening, Wittig reaction, and Wacker oxidation. (C) 2009 Elsevier Ltd. All rights reserved.

DOI10.1016/j.tetlet.2009.09.001
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)2.618
Divison category: 
Organic Chemistry