Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain
| Title | Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Shingate, BB, Liazra, BG, Salunke, DB, Pore, VS, Shirazi, F, Deshpande, MV |
| Journal | European Journal of Medicinal Chemistry |
| Volume | 46 |
| Issue | 9 |
| Pagination | 3681-3689 |
| Date Published | SEP |
| ISSN | 0223-5234 |
| Keywords | antibacterial activity, Antifungal activity, Grignard reaction, Steroid side chain, Steroidal ketones |
| Abstract | Stereoselective synthesis of novel steroidal C-20 tertiary alcohols with thiazole and pyridine side chain using Grignard reaction of steroidal ketones and thiazole/pyridine magnesium bromide have been realized. These molecules were evaluated in vitro for their antifungal and antibacterial activities. Most of the compounds exhibited significant antifungal and antibacterial activity against all the tested strains. (C) 2011 Elsevier Masson SAS. All rights reserved. |
| DOI | 10.1016/j.ejmech.2011.05.032 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.83 |
Divison category:
Biochemical Sciences
Organic Chemistry