Simple synthesis of the novel antihistaminic drug olopatadine hydrochloride
| Title | Simple synthesis of the novel antihistaminic drug olopatadine hydrochloride |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Chavan, SP, Lasonkar, PB |
| Journal | Synthesis-Stuttgart |
| Volume | 45 |
| Issue | 24 |
| Pagination | 3399-3403 |
| Date Published | DEC |
| ISSN | 0039-7881 |
| Keywords | antihistaminic drugs, chelates, Lewis acids, spiro compounds, zinc |
| Abstract | A new alternative route for the synthesis of olopatadine is described. The present strategy involves a Lewis acid mediated ring opening of a cyclic ether to introduce 3-(dimethylamino)propylidene group as the side chain. |
| DOI | 10.1055/s-0033-1340008 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.443 |
Divison category:
Organic Chemistry