Simple procedure for the synthesis of gamma-hydroxy-alpha,beta-(E)-alkenoic esters: formal synthesis of (+)-macrosphelides A and B
| Title | Simple procedure for the synthesis of gamma-hydroxy-alpha,beta-(E)-alkenoic esters: formal synthesis of (+)-macrosphelides A and B |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | K. Rao, S, Mukkanti, K, D. Reddy, S, Pal, M, Lqbal, J |
| Journal | Tetrahedron Letters |
| Volume | 46 |
| Issue | 13 |
| Pagination | 2287-2290 |
| Date Published | MAR |
| Abstract | A highly trans-selective conjugate reduction of 7-hydroxy-alpha,beta-alkynoic esters to produce gamma-hydroxy-alpha,beta-(E)-alkenoic esters using LiAlH4 is reported. The application of this methodology is demonstrated by a formal synthesis of the potent cell-cell adhesion inhibitors (+)-macrosphelides A and B. (c) 2005 Elsevier Ltd. All rights reserved. |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.347 |
Divison category:
Organic Chemistry