Simple, economical, and environmentally benign protocol for the synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature
| Title | Simple, economical, and environmentally benign protocol for the synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Desai, UV, Kulkarni, MA, Pandit, KS, Kulkarni, AM, Wadgaonkar, PP |
| Journal | Green Chemistry Letters and Reviews |
| Volume | 7 |
| Issue | 3 |
| Pagination | 228-235 |
| Date Published | JUN |
| ISSN | 1751-8253 |
| Keywords | 5-dicarbonitriles, diethylamine, green chemistry, multicomponent reactions, organocatalyst, pyridine-3 |
| Abstract | A simple, economical, and environmentally benign protocol has been described for one-pot synthesis of medicinally privileged 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines by three-component condensation between aldehyde, malononitrile, and thiol using diethylamine as a catalyst. Ambient temperature and avoidance of conventional work-up as well as purification procedure qualify this cost-effective protocol for ``green synthesis.'' |
| DOI | 10.1080/17518253.2014.925144 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.512 |
Divison category:
Polymer Science & Engineering