Simple and practical approach to enantiomerically pure (S)-3-hydroxy-gamma-butyrolactone: synthesis of (R)-4-cyano-3-hydroxybutyric acid ethyl ester
| Title | Simple and practical approach to enantiomerically pure (S)-3-hydroxy-gamma-butyrolactone: synthesis of (R)-4-cyano-3-hydroxybutyric acid ethyl ester |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Kumar, P, Deshmukh, AN, Upadhyay, RK, Gurjar, MK |
| Journal | Tetrahedron-Symmetry |
| Volume | 16 |
| Issue | 16 |
| Pagination | 2717-2721 |
| Date Published | AUG |
| Type of Article | Article |
| ISSN | 0957-4166 |
| Abstract | The oxidation of alpha- or beta-(1,4) linked disaccharides or oligosaccharides with cumene hydroperoxide in the presence of a base gave (S)-3,4-dihydroxybutyic acid, which was cyclized under acidic conditions to furnish (S)-3-hydroxy-gamma-butyrolactone. This was subsequently converted into (R)-cyano-3-hydroxybutyric acid ethyl ester, an intermediate for statin based drugs and other related compounds. (c) 2005 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetasy.2005.07.012 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.108 |
Divison category:
Organic Chemistry