Silver-catalyzed cascade cyclization/1,6-conjugate addition of homopropargyl sulfonamides to p-quinone methides: an approach to diverse 3-diarylmethine substituted dihydropyrroles
| Title | Silver-catalyzed cascade cyclization/1,6-conjugate addition of homopropargyl sulfonamides to p-quinone methides: an approach to diverse 3-diarylmethine substituted dihydropyrroles |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Shirsath, SR, Ghotekar, GS, Bahadur, V, Gonnade, RG, Muthukrishnan, M |
| Journal | Journal of Organic Chemistry |
| Volume | 85 |
| Issue | 23 |
| Pagination | 15038-15050 |
| Date Published | DEC |
| Type of Article | Article |
| ISSN | 0022-3263 |
| Abstract | A silver-catalyzed cycloisomerization/1,6-conjugate addition of homopropargyl sulfonamides to p-quinone methides to access diverse diarylmethine substituted dihydropyrroles has been disclosed. The reaction pathway involves an intramolecular cascade cyclization of homopropargyl sulfonamides to generate a highly reactive dihydropyrrole intermediate in situ followed by conjugate addition with p-quinone methides. This method provides an efficient and scalable route for the synthesis of 3-diarylmethine substituted dihydropyrroles, in one pot. |
| DOI | 10.1021/acs.joc.0c01922 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.335 |
Divison category:
Center for Material Characterization (CMC)
Organic Chemistry
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