Silicon-induced general, mild, and efficient one-pot, three-component synthesis of amidoalkyl naphthol libraries

TitleSilicon-induced general, mild, and efficient one-pot, three-component synthesis of amidoalkyl naphthol libraries
Publication TypeJournal Article
Year of Publication2013
AuthorsSalama, TA
JournalSynlett
Volume24
Issue6
Pagination713-718
Date PublishedAPR
ISSN0936-5214
Keywordsamidoalkyl naphthols, combinatorial synthesis, multicomponent reactions, Ritter reaction, tetrachlorosilane
Abstract

A general mild and efficient protocol for the synthesis of amidoalkyl naphthol libraries was achieved utilizing tetrachlorosilane and zinc chloride in dichloromethane at ambient temperature via a one-pot, three-component condensation of various aldehydes, nitriles (amides), and beta-naphthol.

DOI10.1055/s-0032-1318392
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)2.463
Divison category: 
Organic Chemistry