Short enantioselective total synthesis of (+)-tofacitinib
| Title | Short enantioselective total synthesis of (+)-tofacitinib |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Mane, KD, Kamble, RB, Suryavanshi, G |
| Journal | Tetrahedron Letters |
| Volume | 67 |
| Pagination | 152838 |
| Date Published | MAR |
| Type of Article | Article |
| ISSN | 0040-4039 |
| Keywords | aminohydroxylation, Hydrogenation, L-proline, piperidone |
| Abstract | An enantioselective total synthesis of Tofacitinib (CP-690,550), a Janus tyrosine kinase (JAK3) specific inhibitor has been achieved from the readily available 4-piperidone. Proline catalysed hydroxylation is the key step for the synthesis of enantiopure 1-benzyl-4-methylpiperidin-3-ol. (C) 2021 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.tetlet.2021.152838 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.275 |
Divison category:
Chemical Engineering & Process Development