Short and efficient synthetic strategy for the total syntheses of (S)-(+)- and (R)-(-)-Plakolide A
| Title | Short and efficient synthetic strategy for the total syntheses of (S)-(+)- and (R)-(-)-Plakolide A |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Mohapatra, DK, Pramanik, C, Chorghade, MS, Gurjar, MK |
| Journal | European Journal of Organic Chemistry |
| Issue | 30 |
| Pagination | 5059-5063 |
| Date Published | OCT |
| Type of Article | Article |
| ISSN | 1434-193X |
| Keywords | Cross-coupling, epoxidation, inhibitors, olefination |
| Abstract | Concise and efficient total syntheses of anticancer agents (S)(+)-Plakolide A and (R)-(-)-Plakolide A were accomplished in eight steps and an overall yield of 39 % starting from geraniol. The key steps in our strategy are Sharpless asymmetric epoxidation, double elimination, and Stille coupling reactions. |
| DOI | 10.1002/ejoc.200700401 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.068 |
Divison category:
Organic Chemistry