Self-assembly of fluorinated sugar amino acid derived alpha,gamma-cyclic peptides into transmembrane anion transport
| Title | Self-assembly of fluorinated sugar amino acid derived alpha,gamma-cyclic peptides into transmembrane anion transport |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Burade, SS, Saha, T, Bhuma, N, Kumbhar, N, Kotmale, A, Rajamohanan, PR, Gonnade, RG, Talukdar, P, Dhavale, DD |
| Journal | Organic Letters |
| Volume | 19 |
| Issue | 21 |
| Pagination | 5948-5951 |
| Date Published | NOV |
| Abstract | Syntheses of fluorinated sugar amino acid derived alpha,gamma-cyclic tetra- and hexapeptides are reported. The IR, NMR, ESI-MS, CD, and molecular modeling studies of cyclic tetra- and hexapeptides showed C-2 and C-3 symmetric flat oval- and triangular-ring shaped, beta-strand conformations, respectively, which appear to self assemble into nanotubes. The alpha,gamma-cyclic hexapeptide (EC50 = 2.14 mu M) is found to be a more efficient ion transporter than alpha,gamma-cyclic tetrapeptide (EC50 = 14.75 mu M). The anion selectivity and recognition of alpha,gamma-cyclic hexapeptide with NO3- ion is investigated. |
| DOI | 10.1021/acs.orglett.7b02942 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.579 |
Divison category:
Center for Material Characterization (CMC)
Central NMR Facility