Scalable synthesis of silacyclohexanones and ready access to silicon building blocks
| Title | Scalable synthesis of silacyclohexanones and ready access to silicon building blocks |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Ramesh, E, Nandawadekar, LD, Rao, RSreenivasa, D. Reddy, S |
| Journal | Organic Letters |
| Volume | 25 |
| Issue | 37 |
| Pagination | 6881-6885 |
| Date Published | SEP |
| Type of Article | Article |
| ISSN | 1523-7060 |
| Abstract | A simple and efficient two-step method for the synthesis of silacyclohexanones starting from bis(bromoethylsilanes) using TosMIC is presented. The prepared silacyclohexanones were transformed to nine different heterocycles with silicon incorporation. In addition, the developed methodology was used for the synthesis of a sila analogue of the HDAC6 inhibitor tubastatin A. |
| DOI | 10.1021/acs.orglett.3c02561 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 5.2 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)
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