Regio- and stereoselective construction of 1,3,5-triaroylcyclohexanes via KO t Bu-mediated cyclotrimerization of aryl vinyl ketones
| Title | Regio- and stereoselective construction of 1,3,5-triaroylcyclohexanes via KO t Bu-mediated cyclotrimerization of aryl vinyl ketones |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Mahale, SD, Yadav, V, Gonnade, RG, Mhaske, SB |
| Journal | Journal of Organic Chemistry |
| Volume | 89 |
| Issue | 23 |
| Pagination | 17207-17212 |
| Date Published | NOV |
| Type of Article | Article |
| ISSN | 0022-3263 |
| Abstract | Herein, we disclose a simple one-pot method for an efficient regio- and stereoselective synthesis of 1,3,5-triaroylcyclohexanes from aryl vinyl ketones using potassium tert-butoxide. The developed protocol allows the construction of various symmetrically substituted cyclohexanes in good to excellent yields. The major product 2 also can be converted to the product 3 (all equatorial) conveniently by acid catalysis. This protocol features a good substrate scope and functional group compatibility. |
| DOI | 10.1021/acs.joc.4c01695 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.6 |
Divison category:
Organic Chemistry
Physical and Materials Chemistry
Database:
Web of Science (WoS)
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